Hemoglobin F, alkali-resistant hemoglobin, high performance liquid chromatography (HPLC), HbF
This test checks the amount of fetal hemoglobin (HbF) in the blood. Fetal hemoglobin is 1 of many types of hemoglobin. A baby growing in the womb has high levels of HbF. The level of HbF usually drops to tiny amounts about 6 months after birth. In an adult or child, a higher level of HbF can mean you have a blood disorder. These include thalassemia, myeloid leukemia, and sickle cell anemia.
You may need this test if your healthcare provider thinks that you may have a blood disorder related to a high level of HbF. People with most of these disorders don't have symptoms. But may have anemia. Symptoms of anemia can include fatigue, pain, irregular heartbeat, and other heart problems.
The blood disorders are genetic. Because of this, you may need this test if you have a family history of 1 of these diseases.
You may also have a blood smear, iron studies, or DNA analysis. These tests can also diagnose blood disorders related to HbF.
Test results may vary depending on your age, gender, health history, the method used for the test, and other things. Your test results may not mean you have a problem. Ask your healthcare provider what your test results mean for you.
Healthy adults usually only have HbF in tiny amounts. If your amount is higher, you may have a blood disorder, such as thalassemia or sickle cell anemia. Or you may have another condition related to high levels of HbF.
The test is done with a blood sample. A needle is used to draw blood from a vein in your arm or hand.
Having a blood test with a needle has some risks. These include bleeding, infection, bruising, and feeling lightheaded. When the needle pricks your arm or hand, you may feel a slight sting or pain. Afterward, the site may be sore.
If you have higher than normal levels of HbF, you may have anemia, leukemia, or a sickle cell disorder. But this test alone does not tell which condition you might have. Some people with higher levels of HbF don't have any symptoms. More testing is needed to find out the type of your blood disorder.
You don't need to prepare for this test. Tell your healthcare provider about all medicines, herbs, vitamins, and supplements you are taking. This includes medicines that don't need a prescription and any illegal drugs you may use.